Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films

In this study, orodispersible films formed from hydroxypropyl methylcellulose (HPMC) E6 (2, 2.5, and 3%) plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene (PEG)), containing doxazosin mesylate, were prepared by the solvent casting method characterized. Design of experiments (DoE) was used as a statistical tool to facilitate interpretation experimental data allow identification optimal levels factors for maximum formulation performance. Differential scanning calorimetry (DSC) curves X-ray powder diffraction (XRPD) diffractograms showed mesylate amorphization, probably due complexation with polymer (HPMC E6), glass transition temperature reduced adding plasticizer. Fourier transformed infrared (FTIR) spectroscopy results that chemical structure preserved when introduced into matrix, plasticizers, glycerin PEG, affected matrix high intensity. The addition increased elongation at break adhesiveness (Gly > PEG PP), confirming greater plasticizer effect Gly observed in DSC FTIR studies. Greater transparency using PP. citric acid pH modifier fundamental release desirability had profile similar reference product.